乙肝最新药物研究及进展
|
药物名称 |
药用机理 |
厂商* |
网址 |
进展 | |
|
干扰素（Interferons） - 模拟机体自然免疫调节，抑制病毒。 | |||||
|
Interferon alpha2b (Intron A®) |
Immunomodulator |
Schering-Plough |
www.schering.com |
FDA Approved | |
|
There are other brands of interferon approved for HCV treatment, but they have not been FDA-approved for HBV: Wellferon® (Glaxo), Roferon® (Hoffman-La Roche), and Infergen® (Amgen) | |||||
|
核苷类 - 干预病毒DNA聚合酶，抑制病毒DNA复制。 | |||||
|
Lamivudine |
Inhibits viral DNA polymerase |
GlaxoSmithKline,RTP, N.C. |
www.gsk.com |
FDA Approved | |
|
Adefovir Dipivoxil ("Hepsera") |
Inhibits viral DNA polymerase |
Gilead Sciences |
www.gilead.com |
FDA Approved 9/20/02 | |
|
Entecavir |
Inhibits viral DNA polymerase |
Bristol-Myers Squibb, Princeton, N.J. |
www.bms.com |
Phase III | |
|
FTC (Coviracil®) |
Inhibits viral DNA polymerase |
Triangle, RTP, N.C. |
www.tripharm.com |
Phase III | |
|
LdT (Telbivudine) |
Inhibits viral DNA polymerase |
Idenix, Cambridge, MA |
www.idenix.com |
Phase III | |
|
非核苷类抗病毒药物 - 干预病毒蛋白复制 | |||||
|
Bam 205 |
"Small Molecule" |
Novelos, Newton, MA |
http://novelos.com |
Phase II/III China | |
|
Post-Exposure and/or Post-Liver Transplant Treatment | |||||
|
BayHep B® |
HBV Immuneglobulin |
Bayer U.S., |
www.bayer.com |
FDA Approved 1977 | |
|
Nabi-HB® |
HBV Immuneglobulin |
Nabi, Boca Raton, FL |
www.nabi.com |
FDA Approved | |
|
Anti-hepatitis B |
HBV Immuneglobulin |
Cangene, Ontario, Canada |
www.cagene.com |
FDA Filing 2001 | |
